After defeating Osebo the Leopard, Is'nana, the son of Anansi the Spider God of Stories, must now face Queen Mmboro the Hornet, her daughter Princess Kantite, and their family of hornets, wasps, and bees who unite and seek to inject themselves into human beings to take over our reality. Unfortunately caught among the mayhem is the Baptiste family, Leland, Gina, and Jenka, who fight to survive and protect each other at all costs against Queen Mmboro's evil hive. Is'nana must not only test his physically limits but also deal with rising tensions with his father who sees fit to control and protect his every move.
Also, Is'nana travels to Haiti to retrieve the lost dog of Papa Legba, the Loa God of the Crossroads. But can Is'nana successfully match wits with the troublesome Ti-Malice, Uncle Bouki, and Compere Chat while also battling Jeremy Tableau, a trickster with his own ulterior motive?